冬青素A T2S0501

Product Introduction
Bioactivity


英文名: Ilexgenin A

描述: Ilexgenin A 是一种五环三萜类化合物，提取自海南冬青，可用于研究炎症及癌症。

体外活性: Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs.?The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells.?Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL.?Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (21.88 mM)


关键字: inhibit | Inhibitor | pentacyclic | Ilexgenin A | cancer | Ilex | inflammation | hainanensis | triterpenoid

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相关库: Anti-Aging Compound Library | Anti-Tumor Natural Product Library | Immuno-Oncology Compound Library | Selected Plant-Sourced Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Apoptosis Compound Library | Anti-Cardiovascular Disease Compound Library

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