齐墩果酸3-乙酸酯 T2S1396
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 4339-72-4 | ¥1,790.00 | 询底价 |
10 mg | 4339-72-4 | ¥1,070.00 | 询底价 |
5 mg | 4339-72-4 | ¥689.00 | 询底价 |
100 mg | 4339-72-4 | ¥3,930.00 | 询底价 |
1 mg | 4339-72-4 | ¥289.00 | 询底价 |
50 mg | 4339-72-4 | ¥2,680.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 3-O-Acetyloleanolic acid
描述: 3-O-Acetyloleanolic acid 是从 Vigna sinensisK. 种子中提取得到的一种齐墩果醇酸,可诱导癌细胞凋亡并拥有抗血管生成作用。
细胞实验: Modulation of phosphatidylserine externalization during apoptosis was measured using annexin V conjugated with the fluorescent dye fluorescein isothiocyanate (FITC). The HCT-116 cells were seeded onto 6-well plates at a density of 3*10^5 cells/well. After treatment with 25 uM 3-O-acetyloleanolic acid for 6 h, the cells were stained with the annexin V-FITC conjugate, and then imaged at a^40 objective magnification using a confocal laser scanning microscope.
体外活性: Expression of TRAIL-mediated apoptosis signaling-related death receptor DR5 was increased in 3-O-acetyloleanolic acid-treated HCT-116 cells. Activation of caspase-8 and caspase-3, critical mediators of extrinsic apoptosis signaling, was also increased by 3-O-acetyloleanolic acid. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 2.5 mg/mL (5.01 mM)
关键字: Apoptosis | 3 O Acetyloleanolic acid | 3-O-Acetyloleanolic acid | Inhibitor | inhibit | 3OAcetyloleanolic acid
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