化合物CRT0273750 T31101

Product Introduction
Bioactivity


英文名: CRT0273750

描述: CRT0273750 是一种 ATX 抑制剂的先导化合物，可调节血浆中 LPA 水平，用于 ATX/LPA 依赖性癌症模型。

体外活性: CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM[1]. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM)[1].

体内活性: CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase[1].CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 200 mg/ml(397.68 mM)


关键字: blood | ATX/LPA | 4T1 | CRT0273750 | Inhibitor | inhibit | clearance | LPA

相关产品: 4,5-Dimethoxycanthin-6-one | OPC18750 HCl | Enpp-1-IN-14 | Sophoflavescenol | Thioquinapiperifil dihydrochloride | Butein | Carbodenafil | Trapidil | Pimobendan | Piclamilast

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途