化合物FPS-ZM1 T3259
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 945714-67-0 | ¥6,900.00 | 询底价 |
100 mg | 945714-67-0 | ¥2,970.00 | 询底价 |
10 mg | 945714-67-0 | ¥622.00 | 询底价 |
1 mL | 945714-67-0 | ¥455.00 | 询底价 |
1 mg | 945714-67-0 | ¥185.00 | 询底价 |
25 mg | 945714-67-0 | ¥1,120.00 | 询底价 |
200 mg | 945714-67-0 | ¥4,390.00 | 询底价 |
5 mg | 945714-67-0 | ¥413.00 | 询底价 |
50 mg | 945714-67-0 | ¥1,970.00 | 询底价 |
Product Introduction
Bioactivity
英文名: FPS-ZM1
描述: FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂,可阻断 Aβ 与 RAGE 的 V 结构域的结合。
细胞实验: CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference)
激酶实验: Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1].
体外活性: FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1].
体内活性: FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 16.67 mg/mL (50.84 mM)
关键字: β-amyloid peptide | Amyloid-β | Inhibitor | inhibit | FPS-ZM-1 | FPS ZM1 | FPS-ZM1 | FPSZM1 | Abeta
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途