化合物GRA-Ex-25 T3422

Product Introduction
Bioactivity


英文名: GRA Ex-25

描述: GRA Ex-25 (GRA-Ex-25) 是glucagon 受体抑制剂，其对大鼠和人的 glucagon 受体的IC50值分别为 56 和 55 nM。

体外活性: GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2].

体内活性: GRA Ex-25 (3 mg/kg, i.v.) 显著降低了外源性胰高血糖素导致的大鼠模型血糖水平。这种降低血糖水平的作用很可能是由于GRA Ex-25直接抑制了由外源性胰高血糖素刺激的肝脏糖输出[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 32 mg/mL


关键字: GRA Ex-25 | GCGR | inhibit | GRA Ex 25 | Inhibitor | Glucagon Receptor | GRA Ex25

相关产品: GLP-1R modulator C16 | Oxyntomodulin acetate | Retatrutide sodium salt | V-0219 hydrochloride | Mazdutide acetate（2259884-03-0 free base） | L-168049 | PF-06291874 | Tirzepatide sodium salt | Glucagon (19-29), human acetate | NNC-0640

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Inhibitor Library | GPCR Compound Library | Anti-Diabetic Compound Library | Anti-Obesity Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途