他莫利嗪 T34782

Product Introduction
Bioactivity


英文名: Tamolarizine

描述: Tamolarizine (Tamolarizine free base) free base 是一种新型的钙拮抗剂。

体外活性: Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.[1]

体内活性: Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

相关产品: BTT-266 | 15-Methoxypinusolidic acid | Propiverine hydrochloride | Halofuginone | (-)-Praeruptorin A | 2-Aminoethyl diphenylborinate | Norverapamil | Ethyl cinnamate | Cyclopiazonic acid | Ebselen

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途