化合物IMR-1A T3540

Product Introduction
Bioactivity


英文名: IMR-1A

描述: IMR-1A 是 IMR-1 的酸代谢物。IMR-1A 是 Notch 抑制剂，IC50=0.5 μM。IMR-1A 相对于 IMR-1 的效力提高了 50 倍。

体外活性: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).

体内活性: The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.23 mg/mL (13 mM)


关键字: Notch | Inhibitor | inhibit | IMR1A | IMR-1A | IMR 1A | Drug Metabolite

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