化合物NS 638 T3543
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 150493-34-8 | ¥743.00 | 询底价 |
5 mg | 150493-34-8 | ¥778.00 | 询底价 |
2 mg | 150493-34-8 | ¥413.00 | 询底价 |
1 mg | 150493-34-8 | ¥289.00 | 询底价 |
25 mg | 150493-34-8 | ¥2,390.00 | 询底价 |
50 mg | 150493-34-8 | ¥3,880.00 | 询底价 |
10 mg | 150493-34-8 | ¥1,160.00 | 询底价 |
100 mg | 150493-34-8 | ¥5,270.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NS-638
描述: NS-638 是一种 Ca2+ 通道阻滞剂,可阻断 K+ 刺激的细胞内 Ca2+ 升高,IC50值为3.4 μM。
细胞实验: NS-638 is prepared in 1% DMSO and 1% ethanol. The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].
体外活性: NS-638 dose-dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons (IC50: 2.3 and 4.3 μM), respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked (IC50: 3.4 μM). At this concentration, no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells (1-30 μM).
体内活性: In the mouse middle cerebral artery occlusion model, NS-638 administered (50 mg/kg, i.p.) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (168.86 mM)
关键字: Ca channels | Inhibitor | Calcium Channel | inhibit | NS638 | Ca2+ channels | NS-638
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途