(E)-5-(2-Bromovinyl)uracil T35439

Product Introduction
Bioactivity


英文名: (E)-5-(2-Bromovinyl)uracil

描述: (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : 60 mg/mL
PBS (pH 7.2) : 8 mg/mL
DMSO : 53 mg/mL
Ethanol : 0.8 mg/mL


关键字: (E) 5 (2 Bromovinyl)uracil | (E)5(2Bromovinyl)uracil | 5-(2-Bromovinyl)uracil

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途