化合物STO609 T3546

Product Introduction
Bioactivity


英文名: STO-609

描述: STO-609 是一种特异性和细胞渗透性的 Ca2+/钙调蛋白依赖性蛋白激酶激酶抑制剂，用于重组 CaM-KKα 和 CaM-KKβ，Ki 值分别为 80 和 15 ng/mL。它抑制 Hela 细胞溶解物中的 AMP 活化蛋白激酶激酶活性，IC50值约为 0.02 g/ml。

体外活性: STO-609 also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 dose-dependently suppresses the Ca2+-induced activation of CaM-KIV. STO-609 (1μg/mL) significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (80%).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.17 mg/mL (13.26 mM)


关键字: Autophagy | AMP-activated protein kinase | STO609 | AMPK | STO-609 | Calmodulin-dependent protein kinases | Inhibitor | Calmodulin-dependent kinases | CaMK | inhibit

相关产品: Phenoxybenzamine hydrochloride | STO-609 acetate | Perphenazine | KN-92 hydrochloride | CaMKII-IN-1 | KN-93 | Trifluoperazine dihydrochloride | Rottlerin | Melatonin | A-484954

相关库: Antioxidant Compound Library | Anti-Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Metabolism Disease Compound Library | Anti-Ovarian Cancer Compound Library | Antidepressant Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Glycolysis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途