化合物GSK-3β inhibitor 3 T35554

Product Introduction
Bioactivity


英文名: GSK-3β inhibitor 3

描述: GSK-3β inhibitor 3 是一种糖原合成酶激酶 3β（GSK-3β）共价抑制剂 （ IC50 ： 6.6 μM），具有强效性、选择性和不可逆性。GSK-3β inhibitor 3 可用于研究急性早幼粒细胞白血病。

体外活性: GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibited the cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells.[1]GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1]

体内活性: GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) shows T1/2 value 14.2 h, AUC values (AUClast=3503.42 ng/mL•h), and maximum concentration (Cmax=515 ng/mL) in mice.[1] GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth of mice by 75.97% relative to vehicle control.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225.0 mg/mL (687.3 mM)


关键字: GSK-3beta inhibitor 3 | GSK-3β inhibitor 3 | GSK3β inhibitor 3 | GSK 3β inhibitor 3 | GSK-3b inhibitor 3

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相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compound Library

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