化合物CK2 inhibitor 2 T35557
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 2641079-92-5 | ¥15,200.00 | 询底价 |
500 mg | 2641079-92-5 | ¥29,700.00 | 询底价 |
50 mg | 2641079-92-5 | ¥11,200.00 | 询底价 |
1 mg | 2641079-92-5 | ¥1,130.00 | 询底价 |
1 mL | 2641079-92-5 | ¥2,730.00 | 询底价 |
10 mg | 2641079-92-5 | ¥3,990.00 | 询底价 |
5 mg | 2641079-92-5 | ¥2,490.00 | 询底价 |
25 mg | 2641079-92-5 | ¥7,890.00 | 询底价 |
Product Introduction
Bioactivity
英文名: CK2 inhibitor 2
描述: CK2 inhibitor 2 是一种有效的,选择性和口服CK2抑制剂,IC50值为 0.66 nM。CK2 inhibitor 2 对 Clk2 (IC50=32.69 nM)/CK2 显示出高选择性。 CK2 inhibitor 2 表现出良好的抗增殖和抗肿瘤活性。
体外活性: CK2 inhibitor 2 (compound 1c) exhibits effective antiproliferative activities against PC-3, HCT-116, MCF-7, HT-29, T24 and LO2 cells, with IC 50 s of 4.53 μM, 3.07 μM, 7.50 μM, 5.18 μM, 6.10 μM, and 96.68 μM, respectively [1]. CK2 inhibitor 2 (5-20 μM; 24 h) induces apoptosis of HCT-116 cells in a dose-dependent manner. CK2 inhibitor 2 dose-dependently suppresses the expression of p-Akt1 S129 and p-Cdc37 S13 in HCT-116 cells [1]. CK2 inhibitor 2 (1-500 nM) dose-dependently inhibits exogenous ALDH1A1 enzyme activity, with an IC 50 of 0.10 μM [1]. CK2 inhibitor 2 (5-20 μM; 24 h) inhibits the transcription and protein expression of ALDH1A1 in HCT-116 cells [1]. Apoptosis Analysis [1] Cell Line: HCT-116 cells Concentration: 5, 10, 20 μM Incubation Time: 24 hours Result: The apoptotic ratio reached about 55% at the concentration of 20 μM. Western Blot Analysis [1] Cell Line: HCT-116 cells Concentration: 5, 10, 20 μM Incubation Time: 24 hours Result: Inhibited the expression of p-Akt1 S129 and p-Cdc37 S13 in a dose-dependent manner.
体内活性: CK2 inhibitor 2 (60-90 mg/kg; p.o. twice a day for 4 weeks) significantly inhibits the tumor growth dose-dependently with a maximum inhibitory rate of 69% at a dose of 90 mg/kg [1]. CK2 inhibitor 2 (25 mg/kg; a single p.o.) exhibits C max (7017.8 ng/mL), elimination half-life (t 1/2 =6.67 h), and CL (0.60 L/h/kg) in SD rats [1]. Animal Model: Male BALB/c athymic nude mice (5 weeks old; 16-18 g) were injected HCT-116 cells [1] Dosage: 60, 90 mg/kg Administration: P.o. twice a day for 4 weeks Result: Inhibited the tumor growth in a dose-dependent manner. No conspicuous change in body weight. Animal Model: Sprague-Dawley (SD) rats [1] Dosage: 25 mg/kg (Pharmacokinetic Analysis) Administration: A single p.o. Result: C max =7017.8 ng/mL, t 1/2 =6.67 h, CL=0.60 L/h/kg.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (127.28 mM)
关键字: CK-2 inhibitor 2 | CK2 inhibitor 2
相关产品: PF-4800567 | Casein kinase 1δ-IN-6 | CK2-IN-4 | PF-5006739 | Casein kinase 1δ-IN-4 | Emodin | DMAT | TAK-715 | CX-5011 | BMS-863233 HCl
相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途