化合物NIH12848 T3556

Product Introduction
Bioactivity


英文名: NIH-12848

描述: NIH12848 是推定的磷脂酰肌醇 5-磷酸4-激酶 γ (PI5P4Kγ) 抑制剂(IC50:1 μM)。

体外活性: NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes' on the culture dish. NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (142.71 mM)


关键字: Inhibitor | NIH 12848 | NIH12848 | inhibit | NIH-12848

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