BODIPY-aminoacetaldehyde diethyl acetal T35568

Product Introduction
Bioactivity


英文名: BODIPY-aminoacetaldehyde diethyl acetal

描述: BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the efflux pump P-glycoprotein (P-gp) but co-application of BAAA with a P-gp inhibitor, such as verapamil , inhibits BAA efflux.2BAAA-DA has been used to isolate human hematopoietic progenitor cells, which have high ALDH activity, andviaflow cytometry to sort cancer stem cells that contain high levels of ALDH.1,3BAA used in cells can be excited at 488 nm and displays an emission maximum of 512 nm.4

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: BODIPY-aminoacetaldehyde diethyl acetal | BODIPY aminoacetaldehyde diethyl acetal | BODIPYaminoacetaldehyde diethyl acetal

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