SW203668 (trifluoroacetate salt) T35675

Product Introduction
Bioactivity


英文名: SW203668 (trifluoroacetate salt)

描述: SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668.

体内活性: In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol:PBS (pH 7.2) (1:3) : 0.25 mg/mL
DMSO : 20 mg/mL
DMF : 20 mg/mL
Ethanol : 20 mg/mL


关键字: SW203668 (trifluoroacetate salt) | SW-203668 | SW203668 | SW-203668 (trifluoroacetate salt) | SW 203668

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途