AP39 T35860

Product Introduction
Bioactivity


英文名: AP39

描述: AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: PBS (pH 7.2) : 1 mg/mL
DMF : 5 mg/mL
Ethanol : 16 mg/mL
DMSO : 20 mg/mL


关键字: AP 39 | AP-39 | AP39

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途