化合物NSC23005 Sodium T3589

Product Introduction
Bioactivity


英文名: NSC23005 Sodium

描述: NSC23005 sodium 是新型 p18 抑制剂 (ED50=5.21 nM)，在小鼠和人类模型中促进造血干细胞扩增。

细胞实验: NSC23005 sodium is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. c-Kit enriched bone marrow (BM) cells are cultured for 5 days with cytokine combination plus NSC23005 sodium or DMSO. As positive controls, primary uncultured bone marrow cells are treated by ultraviolet radiation (UV) for 10 minutes prior to the staining process for apoptosis analysis. Apoptosis and cell death are measured by AnnexinV and DAPI staining in the Annexin V-FITC Apoptosis Detection Kit. Apoptosis is measured on an FACS analyzer. The data is analyzed using FlowJo software[1].

体外活性: NSC23005 sodium is a novel class of INK4C (p18INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED50=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED50=5.21 nM), shows no activity in promoting the proliferation of leukemia cells.

体内活性: NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models without significant cytotoxicity toward HSCs, nor did it augment leukemia cell proliferation.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (196.52 mM)


关键字: NSC23005 | NSC 23005 | NSC-23005 Sodium | inhibit | NSC-23005 | Inhibitor | NSC23005 Sodium

相关产品: NVP-2 | CDK12-IN-2 | Seliciclib | (S)-Enitociclib | CDK4/6-IN-3 | ALSTERPAULLONE | CDK9-IN-1 | Samuraciclib hydrochloride | Atuveciclib Racemate | CGP60474

相关库: Anti-Breast Cancer Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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