IM-156醋酸盐 T36420

Product Introduction
Bioactivity


英文名: IM-156 acetate

描述: IM-156 acetate 是一种 NADH 脱氢酶（IC50=2.2μM）和 AMP-激活蛋白激酶α（AMPKα）的激活剂，是一种可口服且具有生物利用的线粒体氧化磷酸化（OxPhos）抑制剂。IM-156 acetate 可增加 AMPKα活性，抑制氯己酮诱导的大鼠腹膜纤维化，抑制肿瘤生长 。

体外活性: IM-156 is an inhibitor of mitochondrial complex I, also known as an activator of NADH dehydrogenase (IC50 = 2.2 µM) and AMP-activated protein kinase α (AMPKα).[1][2]

体内活性: It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.[3][4]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1.0mg/mL (3.2mM)
DMF : 1.0mg/mL (3.2mM)
Ethanol : 1 mg/mL


关键字: HL271 Acetate | IM-156 Acetate | IM156 Acetate | HL-271 Acetate | IM 156 Acetate | HL 271 Acetate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途