化合物BGP15 T3649
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 66611-37-8 | ¥496.00 | 询底价 |
2 mg | 66611-37-8 | ¥318.00 | 询底价 |
1 mg | 66611-37-8 | ¥228.00 | 询底价 |
100 mg | 66611-37-8 | ¥4,290.00 | 询底价 |
50 mg | 66611-37-8 | ¥2,650.00 | 询底价 |
1 mL | 66611-37-8 | ¥546.00 | 询底价 |
25 mg | 66611-37-8 | ¥1,590.00 | 询底价 |
10 mg | 66611-37-8 | ¥793.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BGP-15
描述: BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂,IC50和Ki 值分别为 120 和 57 μM,在缺血再灌注损伤后具有保护作用。
细胞实验: Human tumor cell lines A549, HCT-15, HCT-116, and Du-145 were maintained in RPMI 1640 medium supplemented with 10% FCS in humidified air containing 5% CO2. For in vitro cytotoxicity assays, 5×103 to 5×104 cells were plated into the wells of 96-well plates in 100 μL culture medium. On the following day, cells were exposed to BGP-15 (10, 30, 100 μg/mL) and to a series of concentrations of cisplatin either by itself or in combination. Cultures were incubated in a total volume of 200 μL for 3 more days at 37°. Samples were prepared in duplicates or triplicates. Cell growth was evaluated by MTT or SRB assays. Growth inhibition curves were calculated. (Only for Reference)
体外活性: 在两种小鼠模型(将分步发展为心衰和房颤)中,BGP-15可改善心脏功能和减少心率不齐[2].在cisplatin处理前以 BGP-15(100-200 mg/kg,p.o.)处理可阻止或显著抑制cisplatin诱导的急性肾功能衰竭的发展.在cisplatin诱导的肾毒性中,BGP-15对肾脏的抗氧化反应具有显著作用.尽管BGP-15可使肾脏免受肾毒性,但它对细胞生长抑制剂的抗肿瘤效果没有减弱作用.在肾脏,BGP-15可抑制cisplatin诱导的二磷酸腺苷核糖多聚化[1].
体内活性: BGP-15是HSP72的体外诱导物,但仅当与热激共同处理时有效,且不影响HSP90的水平[3]。BGP-15 (200 μM)可使高能磷酸化合物的损耗减弱,并防止imatinib mesylate诱导的氧化性损伤,这是通过诱导Akt和GSK-3beta的磷酸化、阻止p38 MAPK和JNK的激活改变imatinib mesylate的信号通路效应实现的。BGP-15可明显抑制p38和JNK的激活效应,因为在离体灌注心脏中这些激酶可促进细胞死亡和炎症反应[4]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 64 mg/mL (182.2 mM)
Ethanol : 65 mg/mL (185 mM)
DMSO : 65 mg/mL (185 mM)
关键字: inhibit | Inhibitor | PARP | BGP 15 | BGP-15 | poly ADP ribose polymerase
相关产品: Rucaparib | Niraparib tosylate monohyrate | Talazoparib tosylate | PARP-2-IN-3 | BYK204165 | PARP-1-IN-2 | Cearoin | PARP1-IN-8 | AZD5305 | Glycoborinine
相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Ferroptosis Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途