化合物COR659 T36520

Product Introduction
Bioactivity


英文名: COR659

描述: COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。

体外活性: In vitro [35S]GTPγS binding assays on stimulated GABAB and CB1 receptors, in combination with alcohol and chocolate self-administration experiments in rats, were employed to assess the pharmacological profile of this novel set of analogues, using COR659 as reference compound[1].

体内活性: 10-Day treatment with COR659(0, 2.5, 5, and 10 mg/kg; i.p.) produced a dose-related reduction of both alcohol and chocolate self-administration, with limited loss of efficacy on continuing treatment. Acute COR659 suppressed reinstatement of alcohol seeking. Among the 9 tested analogues, only COR657 (methyl 2-(benzoylamino)-4-ethyl-5-methylthiophene-3-carboxylate) decreased alcohol self-administration similarly to COR659; all other compounds produced modest, or even no, effect on alcohol self-administration. COR659 excluded, no compound altered chocolate self-administration[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33.33 mg/mL (98.66 mM)


关键字: Gamma-aminobutyric acid Receptor | sucrose | inhibit | chocolate | γ-Aminobutyric acid Receptor | COR 659 | GABA Receptor | Inhibitor | COR659 | COR-659 | alcohol

相关产品: PSB-SB-487 | CB-25 | JD-5037 | CB1R antagonist 1 | CB1R Allosteric modulator 3 | ML-184 | N-Oleoyl glycine | JTE-907 | β-Caryophyllene | Tetrahydrocannabivarin

相关库: Ion Channel Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途