异脱氧胆酸 T36585

Product Introduction
Bioactivity


英文名: Isodeoxycholic Acid

描述: Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。

体外活性: Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decrease the cytotoxicity of C. difficile culture supernatants to Vero cells.[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : 27.0 mg/mL (68.8 mM)
Ethanol : 18.0 mg/mL (45.8 mM)
DMSO : 18.0 mg/mL (45.8 mM)
DMF:PBS (pH 7.2) (1:1) : 0.5 mg/mL


关键字: Isodeoxycholic Acid

相关产品: Picrotin | Urethane | Ani9 | Lubiprostone | Eact | Hypotaurine | NS1652 | CaCCinh-A01 | Adjudin | Org 25543

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Natural Product Library for HTS | Gut Microbial Metabolite Library | Bioactive Compound Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途