Bisubstrate Inhibitor 78 T36802

Product Introduction
Bioactivity


英文名: Bisubstrate Inhibitor 78

描述: Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when used at a concentration of 100 μM.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : Slightly soluble
Chloroform : Slightly soluble
Ethanol : Slightly soluble
DMSO : Slightly soluble
Methanol : Slightly soluble


关键字: Bisubstrate Inhibitor 78

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途