化合物 Methyl alpha-eleostearate T36889

Product Introduction
Bioactivity


英文名: Methyl alpha-eleostearate

描述: Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL
Ethanol : 100 mg/mL
DMF : 30 mg/mL


关键字: 9(Z),11(E),13(E) Octadecatrienoic Acid methyl ester | Methyl a-eleostearate | Methyl alpha-eleostearate | Methyl α-eleostearate | 9(Z),11(E),13(E)Octadecatrienoic Acid methyl ester

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途