化合物PD-1/PD-L1-IN-NP19 T36900
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 2377916-66-8 | ¥3,860.00 | 询底价 |
2 mg | 2377916-66-8 | ¥2,120.00 | 询底价 |
5 mg | 2377916-66-8 | ¥3,160.00 | 询底价 |
100 mg | 2377916-66-8 | ¥17,500.00 | 询底价 |
50 mg | 2377916-66-8 | ¥13,800.00 | 询底价 |
25 mg | 2377916-66-8 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PD-1/PD-L1-IN-NP19
描述: PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂,抑制人类 PD-1/PD-L1 相互作用的 IC50 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境,这可能有助于其抗肿瘤作用。
体外活性: PD-1/PD-L1-IN-NP19 (compound NP19) (0.37-10 μM; 72 h) significantly elevates the production of IFN-γ in a dose dependent manner from T cells co-cultured with tumor cells[1].PD-1/PD-L1-IN-NP19 exhibits much lower activity for inhibiting mouse PD-1/PD-L1 interaction with an IC50 in the micromolar range (>1μM), as compared to the inhibition of human PD1/PD-L1 interaction (IC50=12.5 nM)[1].PD-1/PD-L1-IN-NP19 (10 μM; 48 h) displays no apparent cytotoxic effects on A549, MCF-7, and B16-F10 cells at a concentration of 10 μM[1].
体内活性: PD-1/PD-L1-IN-NP19 (compound NP19) (25-100 mg/kg; intragastric gavage once daily for 15 d) inhibits the growth of melanoma tumors dramatically in mice[1].PD-1/PD-L1-IN-NP19 (25 mg/kg; i.p. daily for 14 d) demonstrates significant antitumor efficacy with a tumor growth inhibition (TGI) of 76.5% and is well tolerated in an H22 hepatoma mouse model[1].PD-1/PD-L1-IN-NP19 (1 mg/kg; i.v.) shows the half time (t1/2=1.5±0.5 h), clearance rate (CL=0.9±0.2 L/h/kg) and apparent distribution volume (Vss=2.1±0.5 L/kg) in rats[1].PD-1/PD-L1-IN-NP19 (10 mg/kg; p.o.) shows the oral absorption (Tmax=0.6±0.2 h), long half-life (t1/2=10.9±7.7 h) and oral bioavailability (F=5%) in rats[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 1.8 mg/mL (3.2 mM)
关键字: PD-1/PD-L-1-IN-NP19 | PD1/PDL1INNP19 | PD 1/PD L1 IN NP19
相关产品: PDL-1 cpd 10 | Danburstotug | Human PD-L1 inhibitor V | PD-L1-IN-3 | BMS-1001 hydrochloride | PD-1/PD-L1-IN-9 | Pidilizumab | BMS-8 | LSD1-IN-24 | ASC-69
化合物PD-1/PD-L1-IN-NP19 T36900信息由TargetMol中国为您提供,如您想了解更多关于化合物PD-1/PD-L1-IN-NP19 T36900报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途