萘并荧光素 T36953

Product Introduction
Bioactivity


英文名: Naphthofluorescein

描述: Naphthofluorescein （Naphthafluorescein）是一种 Mint3 抑制剂，具有潜在的抗肿瘤和抗炎活性，抑制 HIF-1 和 Mint3 之间的相互作用，抑制 Mint3 依赖性 HIF-1 活性，抑制癌细胞和巨噬细胞的糖酵解活动，同时未显示出明显的体外细胞毒性和体内副作用。Naphthofluorescein 也是一种荧光 pH 敏感探针，可用于功能性切伦科夫成像。

体外活性: Naphthofluorescein（0-10 μM；24小时；HT1080细胞）在浓度依赖的方式中显著抑制HIF-1报告基因活性。[1]

体内活性: Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily; 5 days followed by 2 days off for 2 weeks; Male C57BL/6J mice) significantly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, Naphthofluorescein suppresses tumour growth in human cancer cells in an FIH-1-dependent manner and does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells. At the same time, Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney nor caused severe adverse effects for at least 2 weeks in mice.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 2 mg/mL
DMSO : 100 mg/mL (231.26 mM)
DMF : 10 mg/mL
DMF:PBS (pH 7) (1:10) : 0.09 mg/mL


关键字: Naphthofluorescein

相关产品: Acriflavine Hydrochloride | AFP464 free base | HIF-2α-IN-1 | Sodium Aescinate | Deferoxamine | Acetylarenobufagin | Dapagliflozin | ML228 | Oligomycin | PT-2385

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

萘并荧光素 T36953信息由TargetMol中国为您提供，如您想了解更多关于萘并荧光素 T36953报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途