L-AP4 monohydrate T37127
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 2247534-79-6 | ¥14,600.00 | 询底价 |
50 mg | 2247534-79-6 | ¥9,660.00 | 询底价 |
25 mg | 2247534-79-6 | ¥7,430.00 | 询底价 |
Product Introduction
Bioactivity
英文名: L-AP4 monohydrate
描述: L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
体内活性: L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2]. Animal Model: Rats.[2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: L-AP4 Monohydrate | L-AP4 | L AP4 monohydrate | L-AP-4 monohydrate | LAP4 monohydrate
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途