Reduced Haloperidol T37167

Product Introduction
Bioactivity


英文名: Reduced Haloperidol

描述: Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Dichloromethane : Slightly soluble
Methanol : Slightly soluble


关键字: Reduced Haloperidol

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