4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside T37193

Product Introduction
Bioactivity


英文名: 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

描述: 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-μU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL
DMF : 5 mg/mL


关键字: 4Methylumbelliferyl2acetamido2deoxyβDGlucopyranoside | 4 Methylumbelliferyl 2 acetamido 2 deoxy β D Glucopyranoside

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