Tenofovir diphosphate (sodium salt) T37523

Product Introduction
Bioactivity


英文名: Tenofovir diphosphate (sodium salt)

描述: Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Tris-HCl (pH 7.5) : Soluble


关键字: Tenofovir diphosphate (sodium salt) | Tenofovir | Tenofovir Diphosphate

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