azido-FTY720 T37548
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 μg | 881914-35-8 | ¥2,500.00 | 询底价 |
5 mg | 881914-35-8 | ¥19,300.00 | 询底价 |
100 μg | 881914-35-8 | ¥577.00 | 询底价 |
1 mg | 881914-35-8 | ¥4,440.00 | 询底价 |
Product Introduction
Bioactivity
英文名: azido-FTY720
描述: FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 20 mg/mL
DMF : 20 mg/mL
DMSO : 20 mg/mL
Ethanol:PBS (pH 7.2) (1:1) : 0.2 mg/mL
关键字: azido-FTY 720 | azido FTY720 | azidoFTY720 | azido-FTY-720
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途