Leukotriene C4 methyl ester T37620

Product Introduction
Bioactivity


英文名: Leukotriene C4 methyl ester

描述: Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: PBS (pH 7.2) : 0.15 mg/mL
Ethanol : 1 mg/mL
DMF : 50 mg/mL
DMSO : 50 mg/mL


关键字: Leukotriene C4 methyl ester | Leukotriene C-4 methyl ester

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途