Kaliotoxin T37808

Product Introduction
Bioactivity


英文名: Kaliotoxin

描述: aliotoxin是神经BK型肽基的抑制剂，对Kv通道和钙激活的钾通道能产生特异性抑制。Kaliotoxin对细胞膜电位和神经元兴奋性的调控具有研究意义。其产品编号为 T37808，CAS号为 145199-73-1

体外活性: Kaliotoxin (250 nM) specifically inhibited the overall Ca2+-activated K+ current in the entire cell. The interaction between Kaliotoxin and KCa channels follows a one-to-one way mechanism with Kd of 20 nM.[1]

体内活性: Kaliotoxin (10 ng; Male Sprague–Dawley rats; Intracerebroventricular injection) facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels. Improved learning but not information consolidation. Increased the long-term retrieval of an odor-reward association.[2]

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 2 mg/mL


关键字: Kaliotoxin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途