化合物GLP-1(28-36)amide acetate T37890L

Product Introduction
Bioactivity


英文名: GLP-1(28-36)amide acetate

描述: GLP-1(28-36)amide acetate 抑制线粒体通透性转变，具有抗氧化、抗糖尿病和心脏保护活性。

体外活性: The plasma half-life of GLP-1(28-36)amide acetate is longer in human hepatocytes (24 min) than that in mouse hepatocytes (13 min). GLP-1(28-36)amide acetate (100 nM) on hepatocytes modulates mitochondrial oxidative metabolism including gluconeogenesis in mitochondria of hepatocytes[1].

体内活性: In high-fat diet-fed mice, GLP-1(28-36)amide acetate (18.5 nmol/kg) improved hepatic glucose disposal. In diet-induced obese mice, GLP-1(28-36)amide acetate (18.5 nmol/kg BW/day) diminishes the development of hepatic steatosis. In male C57BL6/J mice, administration of GLP-1(28-36)amide acetate for 20 min to, then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure is significantly great. In a β-cell injury diabetic mouse model, GLP-1(28-36)amide acetate (18 nmol/kg; i.p.) shows cytoprotective effect on pancreatic β cells by promoting proliferation and increasing mass[1].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11.48 mg/mL (10 mM)


关键字: GLP 1(28 36)amide acetate | GLP1(2836)amide acetate | GLP-1amide acetate(1225021-13-5 Free base) | GLP-1amide Acetate

相关产品: Rosmanol | Vicenin-1 | N-Acetyl-L-cysteine ethyl ester | Licoflavone C | Gelsemine | 8-Gingerol | Cowaxanthone B | (5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one | 3-Indolepropionic acid | γ-Terpinene

相关库: Membrane Protein-targeted Compound Library | Peptide Compound Library | Anti-Obesity Compound Library

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