MM 419447 T38482
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1092457-78-7 | ¥8,720.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MM 419447
描述: MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
体外活性: MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].
体内活性: MM 419447 (10 mg/kg; p.o.) treatment shows the C max , AUC 0-6 and t 1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]Animal Model: Female Sprague-Dawley rats[1]Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The C max , AUC 0-6 and T max were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MM-419447 | MM419447 | MM 419447
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途