化合物NCT-504 T38605

Product Introduction
Bioactivity


英文名: NCT-504

描述: NCT-504，作为一种选择性的PIP4Kγ的变构抑制剂，展现出15.8 μM的IC50值。该化合物对于亨廷顿病的研究具有潜力。

体外活性: NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate [1] . NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1] . NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC 50 between 50 μM and 100 μM) at 50 μM concentration [1] . NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs [1] . NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs [1] . NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo [1] . NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes [1] . NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells [1] . NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice [1] . Western Blot Analysis [1] Cell Line: HEK293T cells Concentration: 5 μM, 10 μM Incubation Time: 2 hours, 6 hours Result: Induced autophagosome formation.

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 112.5 mg/mL (278.1 mM)


关键字: NCT-504 | NCT 504 | NCT504

相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途