MPC-0767 T38707

Product Introduction
Bioactivity


英文名: MPC-0767

描述: MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.

体内活性: MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the T max , C max , AUC and F% are 1?(h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1].MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1].MPC-0767 is well tolerated when administered at 252?mg/kg po (equivalent to 200?mg/kg dose of?MPC-3100)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MPC0767 | MPC 0767 | MPC-0767

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途