SR-1277 T38927
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1446715-47-4 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: SR-1277
描述: SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.
体外活性: SR-1277 exhibits antiproliferative effects in A375 cells, with an EC 50 of 22 nM[1].
体内活性: SR-1277 (1 mg/kg; i.v.) exhibits C max (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM?h), T 1/2 (1.42 h) and brain penetration (24%) in mice[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: SR1277 | SR-1277 | SR 1277
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途