化合物YM-244769 dihydrochloride T39195

Product Introduction
Bioactivity


英文名: YM-244769 dihydrochloride

描述: YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂，IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。

体外活性: YM-244769 dihydrochloride (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1). YM-244769 dihydrochloride (0.003-1 μM) inhibits the initial rates of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 dihydrochloride is approximately four to five times more selective to NCX3 than other isoforms[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 95 mg/mL (183.97 mM)


关键字: NCX3 | inhibit | Na+/Ca2+ exchange | anti-ischemic | YM244769 Dihydrochloride | nicotinamide | Na+/Ca2+ Exchanger | SH-SY5Y cells | LLC-PK1 cells | YM 244769 dihydrochloride | Inhibitor | neuroprotective | NCX2 | YM 244769 Dihydrochloride | YM 244769 | YM244769 | NCX1 | YM-244769 Dihydrochloride | YM-244769 | YM244769 dihydrochloride

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