Idroxioleic acid T39265

Product Introduction
Bioactivity


英文名: Idroxioleic acid

描述: Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) is the R enantiomer of (Rac)-Idroxioleic acid. It is an orally active fatty acid known for its ability to modulate the lipid composition and structure of membranes. With demonstrated antitumor activities, Idroxioleic acid plays a significant role in the field of cancer research.

体外活性: Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC 50 of 252 μM[1].

体内活性: Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days[1]. Animal Model: Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells[1]Dosage: 400 mg/kg Administration: p.o.; daily; for 21 days Result: Caused a reduction in tumor volume of about 20-25% after 21 days.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Idroxioleic acid | 2-OHOA | 2-Hydroxyoleic acid

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