AM404 T39281

Product Introduction
Bioactivity


英文名: AM404

描述: AM404 is a chemical compound that functions as an inhibitor of endocannabinoid reuptake. It effectively blocks the transport of anandamide, with IC50 values measured in the low micromolar range. Moreover, AM404 exhibits the ability to induce relaxation in rat isolated hepatic arteries contracted with Phenylephrine. This relaxation effect is quantified by a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Additionally, AM404 possesses a neuroprotective effect.

体外活性: AM404 reduces C6 glioma cell proliferation with IC 50 values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide[2]. Cell Viability Assay[2]Cell Line: Rat C6 glioma cells Concentration: 1, 3, 10 and 30 μM Incubation Time: 24, 48, 72 and 96 h Result: Produced a concentration-dependent reduction in cell proliferation that was seen with 24 h of exposure to 10 and 30 μM concentrations and after 48 h at 3 μM. The lowest concentration of AM404 tested, 1 μM, produced a significant, albeit small, reduction in cell proliferation at 72 h.

体内活性: AM404 (1-5?mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations. Animal Model: Adult male Sprague-Dawley rats (250-300?g)[2]Dosage: 2.5-10?mg/kg Administration: Intraperitoneal (i.p.) Result: Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: AM 404 | AM-404 | AM404

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途