化合物CC-99677 T39321

Product Introduction
Bioactivity


英文名: CC-99677

描述: CC-99677 (Gamcemetinib) 是一种一种用于自身免疫性疾病的选择性靶向共价MAPKAPK2(MK2)抑制剂，通过亲核芳族取代(SNAr)机制将生化效力转化为LPS活化的单核细胞THP-27细胞中热休克蛋白27(HSP1)磷酸化的有效抑制所显示的细胞效力。CC-99677 在大鼠实验中展现出在生化(IC 50 =156.3 nM)和细胞检测(EC 50 =89 nM)中均有

体外活性: CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50 =156.3 nM) and cell based assays ( EC50 =89 nM).[1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 14.10 mg/mL (30 mM)


关键字: CC-99677

相关产品: PU-H71 HCl | Zelavespib hydrochloride | TRC051384 HCl | TRC051384 | Col003 | Myricanone | Grp94 Inhibitor-1 | HSP90-IN-25 | VER-49009 | Feretoside

相关库: Drug Repurposing Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途