MW-150 hydrochloride T39343

Product Introduction
Bioactivity


英文名: MW-150 hydrochloride

描述: MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.

体外活性: MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1]. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC 50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1].

体内活性: MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; oral daily for 3?4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1]. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP NLh/NLh × PS P264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1]. Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]Dosage: 2.5 mg/kg Administration: Oral daily; 3-4 months (until cognitive impairment is present) Result: Improved the Tg mice performance in both cognitive tests.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MW150 hydrochloride | MW150 Hydrochloride | MW 150 Hydrochloride | MW01-18-150SRM Hydrochloride | MW 150 hydrochloride | MW-150 Hydrochloride

MW-150 hydrochloride T39343信息由TargetMol中国为您提供，如您想了解更多关于MW-150 hydrochloride T39343报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途