PIP4K-IN-a131 T39452
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2055405-95-1 | ¥8,400.00 | 询底价 |
2 mg | 2055405-95-1 | ¥1,670.00 | 询底价 |
5 mg | 2055405-95-1 | ¥2,490.00 | 询底价 |
100 mg | 2055405-95-1 | ¥15,800.00 | 询底价 |
50 mg | 2055405-95-1 | ¥10,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PIP4K-IN-a131
描述: PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC 50 s of 1.9 μM and 0.6 μM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways.
体外活性: PIP4K-IN-a131 (0-100 μM; 72?hours) is a potent antiproliferative agent with a clear selectivity toward cancer cells killing[1]. PIP4K-IN-a131 eliminates cancer cells via a dual-inhibitory mechanism[1]. PIP4K-IN-a131 causes inhibition of the PI3K/Akt/mTOR pathway only in normal BJ cells, but not in transformed counterparts[1]. Inhibition of PIP4Ks by PIP4K-IN-a131 arrests normal cells at the G1/S phase of the cell cycle by suppressing the PI3K/Akt/mTOR signaling pathway via transcriptional upregulation of PIK3IP1[1]. Cell Proliferation Assay[1]Cell Line: Normal and transformed BJ cells Concentration: 0-100 μM (MTT assay) Incubation Time: 72?hours Result: Selective killed cancer cells. RT-PCR[1]Cell Line: BJ cells Concentration: 5?μM Incubation Time: 24?hours Result: Induced the upregulation of PIK3IP1 mRNA levels.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: PIP-4K-IN-a131 | PIP4K IN a131 | PIP4KINa131
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途