THZ-P1-2 T39459

Product Introduction
Bioactivity


英文名: THZ-P1-2

描述: THZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kα. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kα by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kα/β/γ. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications.

体外活性: THZ-P1-2 (0.2-11.4 μM) exhibits approximately 75% inhibition of PI-4,5-P2 formation by PI5P4Kα and PI5P4Kγ and 50% inhibition by PI5P4Kβ at a concentration of 0.7 μM[1]. THZ-P1-2 (10-100000 nM; 72 hours) shows modest anti-proliferative activity in all six AML/ALL cell lines with IC 50 values in the low micromolar range[1]. Cell Proliferation Assay[1]Cell Line: THP1, SEMK2, OCI/AML-2, HL60, SKM1, NOMO1 cells Concentration: 10-100000 nM Incubation Time: 72 hours Result: Showed anti-proliferative activity in all six AML/ALL cell lines with IC 50 values ranging from 0.87 to 3.95 μM.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: THZ P1 2 | THZ-P-1-2 | THZP12

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途