化合物NLG802 T39476
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 2071683-99-1 | ¥1,280.00 | 询底价 |
1 mg | 2071683-99-1 | ¥549.00 | 询底价 |
100 mg | 2071683-99-1 | ¥6,860.00 | 询底价 |
10 mg | 2071683-99-1 | ¥1,980.00 | 询底价 |
25 mg | 2071683-99-1 | ¥3,370.00 | 询底价 |
50 mg | 2071683-99-1 | ¥4,890.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NLG802
描述: NLG802 是 indoximod 的前药,indoximod 是一种口服活性的吲哚胺2,3-双加氧酶(IDO)抑制剂。
体外活性: NLG802 showed moderate direct (IC50 5 μM) and time dependent (7-fold shift) inhibition of CYP3A4, weak inhibition to CYP2D6 (IC50 19 μM) and CYP2C19 (IC50 47 μM), no inhibition of CYP450 1A2, 2B6, 2C8 and 2C9 (IC50 > 50 μM) and no induction of CYP1A2, 2B6 or 3A4 in human hepatocytes. NLG802 showed moderate inhibition of P-gp transporter activity in MDR1-MDCKII cells (IC50 27 μM), does not inhibit the anion and cation transporters OATP1B1, OATP1B3, OAT1, OAT3, OCT1 and OCT2 in HEK293 cells expressing these transporters (IC50 > 50 μM) or the BRCP transporter in Caco-2 cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 225 mg/mL (568.3 mM)
关键字: NLG802 | NLG-802 | NLG 802
相关产品: IDO1-IN-5 | Coptisine chloride | PF-06840003 | IDO1-IN-22 | Epacadostat | Indoximod | IDO1-IN-21 | IDO1/TDO-IN-6 | 1-Isopropyltryptophan | 4-Phenyl-1H-1,2,3-triazole
相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Immuno-Oncology Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途