MK-6884 T39545

Product Introduction
Bioactivity


英文名: MK-6884

描述: MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can be efficiently radiolabeled with carbon-11, enabling its use as a PET imaging agent.

体外活性: MK-6884 (compound 13; 0-22 μM) is a PAM of ACh function in a cell-based Ca 2+ mobilization assay, with an EC 50 of 27 nM[1].

体内活性: [ 11 C]MK-6884 (compound 13) shows non-displaceable binding potential (BP ND ) of 0.83 in rhesus monkeys[1]. [ 11 C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain[1]. [ 11 C]MK-688 can penetrate the blood-brain barrier in monkeys[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MK6884 | MK-6884 | MK 6884

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途