BRK inhibitor P21d hydrochloride T39772
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 2250025-98-8 | ¥38,300.00 | 询底价 |
25 mg | 2250025-98-8 | ¥16,700.00 | 询底价 |
50 mg | 2250025-98-8 | ¥25,300.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BRK inhibitor P21d hydrochloride
描述: BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.
体外活性: BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC 50 >20 μM) and Lck (IC 50 >20 μM)[1].
体内活性: BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC 0–6h =31.1 μM?h,C 6h =3.5 μM)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BRK inhibitor P21d Hydrochloride | BRK inhibitor P-21d hydrochloride
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途