TH5427 hydrochloride T39785
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 2253744-57-7 | ¥3,340.00 | 询底价 |
Product Introduction
Bioactivity
英文名: TH5427 hydrochloride
描述: TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
体外活性: TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47D WT cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: TH-5427 Hydrochloride | TH 5427 Hydrochloride | TH5427 Hydrochloride | TH5427 hydrochloride | TH-5427 hydrochloride
TH5427 hydrochloride T39785信息由TargetMol中国为您提供,如您想了解更多关于TH5427 hydrochloride T39785报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途