化合物SMI-16a T3989

Product Introduction
Bioactivity


英文名: SMI-16a

描述: SMI-16a (PIM1/2 Kinase Inhibitor VI) 是选择性 Pim 激酶抑制剂，对 Pim1、Pim2 和 PC3 细胞的 IC50值分别为0.15、0.02 和48 μM。

激酶实验: Competition binding reactions used 25 μg human M1 CHO membrane protein, BQCA or vehicle, and 0.15 nM [3H]NMS in 96-well deep-well plates. Binding reactions (30 °C for 2-3 h) are terminated by rapid filtration. Nonspecific binding is determined by adding 10 μM atropine. Filter plates are ished 4×with ice-cold 20 mM HEPES, 100 mM NaCl, and 5 mM MgCl2, pH 7.4 using a 96-well harvester. Plates are dried and radioactivity counted with a microplate scintillation counter[1].

体外活性: PIM1/2 Kinase Inhibitor VI exhibits antitumor activity in PC3 human prostate cancer cultures in vitro (IC50: 48 μM).

体内活性: PIM1/2 Kinase Inhibitor VI exhibits antitumor activity in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg/day, i.p.).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 150 mg/mL (569.67 mM)


关键字: SMI 16a | SMI-16a | inhibit | SMI16a | Pim | Inhibitor | Pim kinases

相关产品: Quercetagetin | HTH-01-091 | Pim-1 kinase inhibitor 8 | GDC-0339 | SGI-1776 | (Z)-SMI-4a | Uzansertib phosphate | TCS PIM-1 1 | HS94 | CK2/ERK8-IN-1

相关库: JAK-STAT Compound Library | Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Apoptosis Compound Library | Anti-Pancreatic Cancer Compound Library | Covalent Inhibitor Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途