一叶秋碱 T3S2100

Product Introduction
Bioactivity


英文名: (-)-Securinine

描述: (-)-Securinine (Securinine) 是来自叶底珠的一种生物碱，也是 GABAA 受体拮抗剂。

体外活性: (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.

体内活性: In the tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle-treated mice at the end of the study period.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2 mg/mL (9.21 mM)


关键字: ()Securinine | inhibit | Inhibitor | GABA Receptor | Gamma-aminobutyric acid Receptor | ( ) Securinine | γ-Aminobutyric acid Receptor

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相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Anti-Alzheimer's Disease Compound Library

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